When you take supplements like VITAcure METHYL PLUS and SAM-e and other supplements with high active nutritional content (but no water), your body will need more water than before. Besides, increased methylation also increases the need to hydrate. Drink several times during the day (drinking everything at once does not help much). Failure to do so will often cause dehydration. If you get headaches, this is usually the cause. Being dehydrated over time can cause other problems.