Articles/NEWS

MTHFR debunked

MTHFR debunked

This interesting article explains in detail many of the wrong assumptions of the so-called "MTHFR-experts". It shows why some of their assumptions are based on facts almost pulled out of thin air. And it raises the question of how they can be sure about suggesting supplements based on single mutations. We look at the science behind it. One assumption among "MTHFR-experts" is that homozyguous mutation in MTHFR C677T results in activity reduction of 70% of this single SNP (single nucleotide polymorphism), and that is far from proven. Another assumption is that the same mutation results in folate deficiency, and that is far from...

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Human Study Confirms Potent Antidepressant Effects of SAM-e

Read this interesting study on how SAMe has improved the lives of those showing resistance to anti-depressants (From LifeExtension®*): Human Study Confirms Potent Antidepressant Effects of SAM-e Life Extension® introduced SAMe (S-AdenosylMethionine) in 1997. Back then it was enormously popular in Europe, but unknown in the United States.  The National Institute of Mental Health decided to fund a double-blind, placebo-controlled trial that would evaluate SAMe as an additive therapy in those suffering major depression  who were resistant to FDA-approved drugs.  Researchers at Harvard Medical School and Massachusetts General Hospital gave patients 800mg of SAMe twice daily along with a selective serotonin...

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Difference undermethylated vs. overmethylated (symptoms)

This is a rough comparison of undermethylated vs. overmethylated people to give you an idea of which category you are in. If you have some/more of the undermethylation symptoms and none/few of the overmethylation symptoms you are most likely in the undermethylation group of people. We might update this post with more symptoms/corrections. Many of the "problems" we can learn to live with and get used to of course, so with age some problems might diminish. Undermethylated people tends to have more obsessive-compulsive tendecies (OCD), addictiveness, and can also be quite agressive. Delusions, brain fog etc. are also typical for undermethylators....

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Methylfolate - the "suicidal" nutrient (don't believe the hype)

Large doses of methylfolate should be avoided for undermethylated depressives (it will make depression worse), only a small dose is beneficial when you are undermethylated (we all need some folate, but too much can make you feel worse). There are 2 reasons you should not take too much if you are undermethylated: 1. Folate tends to accumulate and trap methyl. As long as you supplement or get only the folate from diet that you actually use, it is helpful, but if you supplement, or eat too much folate-rich food, it will build up and actually slow down methylation if there is not enough...

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Why not only SAM-e?

Most undermethylators are low in "everything" (homocysteine, SAMe, methionine, B6, Calcium, Magnesium, Zinc, Glutathione, Creatine etc.) and what they need is more methyl. VITAcure Methyl Plus contains "everything" except SAM-e. An exception to this is folate: folate is important in the methylation cycle*, but undermethylators are often too high in folate, and folate tends to accumulate and trap methyl, so avoid supplementation of high dose (but some is eventually necessary)! Initially homocysteine is TOO LOW with undermethylators. That could cause some problems since SAM-e is converted from Methionine in our cells, which again is converted from homocysteine. When there is not...

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How do you know if you are undermethylated?

Just because you have a MTHFR C677T/A1298C mutation doesn’t actually mean you’re over or under methylated (although it would be one factor that might push the balance to undermethylation). Dr. Walsh (Walsh Research Institute) describes one’s methylation status as being like a tug of war between opposing factors. Many of those are genetic and some are nutritional or environmental. According to Dr. Walsh’s research, 70% of the population are normal methylators, 22% are undermethylators and 8% are overmethylators, but this again may depend on what you define as under/over-methylation/normal. Pfeiffer statistic say 45% are under-methylators and 15% are over-methylators (only 40%...

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The new product: VITAcure® Methyl Plus™ is now in stock

February 2017: Finally our new and unique product: VITAcure Methyl Plus™ is in stock here in the US (Massachusetts) ready to be shipped today both within the US and to the rest of the world. This is a specially tailored product for people who are undermethylated. To increase methylation one might also want to take SAM-e. It is very important to take cofactors in addition to the methyl-donator SAM-e to get the methionine-cycle functioning as it should. Before this supplement was available, one would have to source a number of different nutrients in addition to SAM-e, but finally there is one product that covers almost everything....

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