SAMe (S-Adenosyl-Methionine) 400mg 60 tablets/servings
SAMe (S-Adenosyl-Methionine) 400mg 60 tablets/servings

SAMe (S-Adenosyl-Methionine) 400mg 60 tablets/servings

Regular price $49.00

Each tablet is packaged separately in the blister pack and enteric coated for protection from moisture/light to ensure a biologically active product (SAMe is unstable and needs extra protection).

60 Tablets, 400mg SAMe (S-Adenosyl-Methionine) in each tablet. 

SAMe is a naturally occurring molecule found in all living cells, but many are depleted. SAMe gives away a methyl group when converted to SAH in your cells, and is the key nutrient in the methylation cycle.

SAMe is largely known for its effects on optimal mood and has also shown benefits for the liver, brain, and joints.

SAMe may become depleted with sickness, age or slow methylation. Supplementing with SAMe plus folate, trimethylglycine (TMG or betaine), vitamins B6 and B12 appears to be an effective way to overcome this deficiency. You will find all the cofactors in VITAcure Methyl Plus.

SAMe is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones, nucleic acids, proteins, and phospholipids, and catecholamines and other neurotransmitters. SAMe is required for the synthesis of norepinephrine, dopamine, and serotonin. SAMe facilitates glutathione usage, which improves the antioxidant defense. It also helps maintain acetylcholine levels which are necessary for cognitive function.

SAMe is used by the body in three important pathwaysMethylation (contributing methyl groups to activate certain molecules), The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.) & Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals).

Caution: SAMe should not be taken by those diagnosed with bipolar disorder, especially over-methylated (the undermethylated bipolar might take SAMe when depressed, but watch out for signs of mania and then stop if mania is approaching). 

Supplement Facts:

Serving Size: 1 enteric coated tablet.

Amount Per Serving: S-Adenosyl-Methionine...400 mg.

Other Ingredients: cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, stearic acid, silica, glyceryl triacetate, sodium starch glycolate, croscarmellose sodium, titanium dioxide, yellow ochre. 

Dosage and Use: Take one (1) tablet one to three times daily in divided doses, preferably on an empty stomach, or as recommended by a healthcare practitioner. Take with co-factors. 


When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.


For other references go to manufacturers page:

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    • Is it safe to use SAMe for extended periods ... a year ... six months .. more?

      SAMe is produced naturally in the body, so it is not toxic. Some produce more than normal amounts (overmethylated) and some produce less than normal (undermethylated). Overmethylators should not take SAMe (they will soon notice it is more than enough anyway). Undermethylators will feel better when taking SAMe (up to a certain amount which is individual and can change a little from time to time). The only thing that can be harmful in the long run is too high Homocysteine levels, since SAMe is converted into Homocysteine. Homocysteine is converted back to SAMe (and to Cysteine using B6). Read more here:
      Undermethylators are usually low on "everything", so taking TMG, B12, B6, B2, Zinc, Magnesium, Calcium etc. is crucial. If you also take the cofactors (like the ones in VITAcure Methyl Plus) you should be safer. However, if you want to be 100% sure you should test your Homocysteine level. Usually undermethylators (who benefit from SAMe) do have low Homocysteine levels, so this tends not to be a problem. It is overmethylators who produce too much SAMe who usually end up with high Homocysteine. If your Homocysteine level is not too high it is safe to take for as many years as you like (it also has many other healthy benefits).

    • How is the pills packaged are they packaged separate or just all in a bottle?

      Important for SAMe: Each SAMe tablet is packaged separate in blister pack and enteric coated to protect it from light and moisture (SAMe is unstable and needs extra protection).