Methyl Plus (90 tablets) 30 servings
Methyl Plus (90 tablets) 30 servings
Methyl Plus (90 tablets) 30 servings
Methyl Plus (90 tablets) 30 servings
Methyl Plus (90 tablets) 30 servings
Methyl Plus (90 tablets) 30 servings

Methyl Plus (90 tablets) 30 servings

Sale price $24.50 Regular price $39.90

Also available on (temporary sold out) and

Temporarily sold out in the USA: new stock arrives soon, however, if you have bought this product before and depend on this product and will run out of your current supply within one week, please send us a message, and we will help you out with advice and give you shipping priority.


Undermethylation vitamins and minerals.

Natural, Fragrance-Free, Vegan, Gluten Free, Soy Free, Dairy Free undermethylation supplement (in addition to SAM-e), packed with only the best active nutrients for the under-methylator. Manufactured in the USA (GMP compliant facility).

It is designed to help with MTHFR (MTHFR is divided into two groups: Undermethylator and Overmethylator, and most are in the first group. If you are in the second, however, the supplementation should be different). Read our Articles/NEWS for more information.

Note: This product is designed to work together with SAM-e to help the methylation cycle speed up. If you do not have SAM-e already, please order it now (SAM-e should be taken separately as a methyl-donor, especially in the early stage).

If you came here for methylfolate, please read this: (Blog) "Methylfolate - the "suicidal" nutrient (don't believe the hype)" (we all need some folate, but too much can make you feel worse).

Blog: Why not only SAM-e?

Cofactors for the "under-methylator". These nutrients are aimed for those who are undermethylated (if you do not know, you should check first or consult with your nutritionally aware practitioner).

Blog: How do you know if you are undermethylated?

The easiest way (no more pill organizers) to get all your nutrients in the best forms (no compromises). Plus it will save you money, time compared to buying every nutrient separate (planning and preparation to get everything you need) and extra fillers, etc. (we have managed to squeeze as many and much of each essential nutrient as possible into each tablet - avoiding unnecessary fillers).

Contains only the best forms of each nutrient (best active forms suitable to aid in the methylation cycle): 

Download XLS-file for calculation for other numbers of tablets


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Customer Reviews

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Questions & Answers

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  • What is this used FOr exactly? Will it help for narcolepsy

    It is used for "undermethylators" (at least 22% or perhaps up to 40% of the general population). We do recommend it for others but it has plenty of benefits for this group. Se comparison of symptoms:  Typically this means LOW serotonin, but also low Dopamine and Norepinephrine. Only if narcolepsy is caused by any of the related symptoms, it can help for this.

  • This formula is just what I need and I love it, but I'm worried about the titanium dioxide coating. There are numerous sources now saying that this substance should be avoided. The International Agency for Research on Cancer has classified titanium dioxide as a group 2B carcinogen. Could you please consider using a safe and inert pharmaceutical glaze, such as carnuba wax, as a coating instead?

    I guess that is nanoparticles used in sunscreens? Food grade does not contain nanoparticles (still coating might change soon).

  • My symptoms and history all strongly suggest undermethylation. However, I also seem to be very sensitive to SAM-e and other methyl donors. Is this common? Do I just need to take it slow, or might I actually be overmethylating?

      Physical symptoms are usually more certain than mental symptoms. If SAM/SAH blood test is available, that could confirm methylation status. You should also start slow with SAM-e, not more than 400mg first week(s). If 400mg is a problem, undermethylation might not be the cause.

  • I'd like to ask again about the Titanium Dioxide coating. I love the tablets but I'm leery of this coating material, as it's reportedly carcinogenic according to some sources. It's hard to believe you would sell something unsafe, so please share with me the evidence you rely upon that would show it as being safe. I've taken other large tablets that use riboflavin or carnuba wax or other safe vegetable coatings, and would love to know whether that would be a future option you would consider in manufacturing Methy-Plus. Thanks again for your time and I sincerely hope to hear a response. I'm just one lone undermethylator out there looking for answers. Thanks, J.C.

    Thank you for your comment. We are working on an updated version, so your comment will be taken into consideration. Please note that this Titanium Dioxide contains no nanoparticles! Nanoparticles are typically smaller than 100 nanometers in diameter, yet most of the particles in food grade titanium dioxide are much larger. The FDA has approved the safety of titanium dioxide for use as a colorant in food, drugs, and cosmetics, including sunscreens. However, controversy exists as to the safety of titanium dioxide nanoparticles used in the cosmetics industry, for example in sunscreens. Titanium and zinc oxides may be made into the nanoparticle size (0.2-100 nanometers) to reduce the white appearance when applied topically, but retain the UV blocking properties. Recent studies suggest titanium dioxide NANOPARTICLES may be toxic, although further research is needed. These nano-particles are believed to be capable of crossing the skin barrier.  Evaluations of titanium dioxide by JECFA and EFSA have each concluded that there are no safety concerns associated with the use of titanium dioxide as a food additive at levels ranging up to 3% (100g serving of a dairy product could contain up to 3g (3000mg) of titanium dioxide, and of course the coating on the tablets is minimal compared to this).

  • Why doesn't this have any b3(niacin) in it?

    B3 traps methyl molecules and increases histamine production. For undermethylators too much should be avoided since methyl molecules are in shortage and histamine is high. Usually, B3 from the diet is enough. B3 is also a precursor to Nicotinamide adenine dinucleotide reduced (NADH) which the supplement does contain.

  • Is this appropriate for a 9 year old? Can the tablets be crushed?

    Yes, the tablets can be crushed. 3 tablets is recommended for adults, so perhaps not more than 1 (or 2 tablets depending on weight compared to adult).

  • how much will kill you? i want to make sure before i give my daughter some

    Usually even adults should not take more than 3 tablets. It will not kill you, but more is not better. Taking the proper amount is most helpful. The tolerable upper intake levels (UL) for: Vitamin C: 1,200mg daily for children 9-13 (3 tablets: 500mg),  B6: 60 mg/day (9–13 years) (3 tablets: 50mg),  Calcium: 3000mg (9–18 years) (3 tablets: 100mg),  Magnesium: 350mg (9–18 years) (3 tablets: 100mg),  Zinc: 23mg (9–13 years) (3 tablets: 25mg),  Selenium: 280mcg (9–13 years) (3 tablets: 50mcg),  All other ingredients: no upper intake level established (or is much higher than serving size). The only worry is B6 and Zinc. If zinc is low as it usually is for undermethylators (for instance white spots on fingernails) 3 tablets is not a problem. If else, go down to maximum 2 tablets for 9 year old (or even less if younger).

  • Why is the dosage for the methylfolate so low?

    Please read here: .
    Methylfolate helps often the first few days only if methylfolate dosage is high, then it can build up and cause more problems than being helpful if you do not use everything.

  • Please can you confirm the levels of lead per tablet cautioned on the side? This appears to be perfect but need reassurance that the levels are not toxic. Kind regards

    It is one of requirements under current Good Manufacturing Practices (cGMP) if we are to sell this product in California according to Prop-65, and is nothing to worry about. Please read more about this here:

  • I am allergic to yeast. Is the yeast from the selenium enough to affect me?

    As far as I know there should be no yeast at all. It is just that the selenium is from yeast which is the best available/active form. So no yeast in our supplement, only selenium and the other nutrients and regular protective coating. However if there should be any trace of yeast left which would make you react, we will of course offer the money back even after you have tried it.

  • I was told not to take any folic acid supplements as an undermethylator. Is this product safe for me considering it has folic acid in it?

    First: it does not contain "folic acid", but the more bioavailable form of folate: l-methylfolate (and a very small dose of that). You are correct about not taking a separate methylfolate (or other folate supplement) as an undermethylator. This is also described in our blog: .  
    Most supplements contain way too much, and taking large doses will not help undermethylation in the long run, unless you keep the dose at such a low level that everything is used. This supplement (VITAcure Methyl Plus) contains a very low dose of methylfolate only: less than 17mcg in each tablet (if you take 3 throughout the day it will be total of only 50mcg). That's only as much folate as what's in about 6 grams of liver (or 19 grams in 3 tablets). If you take no more than what you use every day you are absolutely safe. You could start off slowly with only 1 tablet a day. The other co-factors in this supplement helps you use the folate. It is also important to take SAM-e to get folate level down and start methylation, and it is more important to not overdo with folate rich foods (for instance: Garbanzo beans (chickpeas), Liver, Pinto beans, Lentils, Spinach, Asparagus, Avocado, Beets, Black eyed peas & Broccoli). Contrary to some claims/misinformation, natural folate is not better, and too much methylfolate is not good for undermethylators (MTHFR or NOT).

  • I am taking this product without SAM-e , do i need to take it with SAM-e to get a difference?

    Yes, in most cases with undermethylation SAM-e is needed especially in the early phase (first months). SAM-e is needed to get methylation started. SAM-e should be taken, perhaps only one tablet first week or two, then increase if slight improvement or no difference. If any improvement, continue, and more improvements can be expected the first 3 months. Do not take too many Methyl Plus (also increase up to 3). Later SAM-e could be reduced if you have improved your methylation (this is different from individual to individual). For some, SAM-e is not needed anymore after several months, others might need to keep taking to avoid going back to the low methylation level you started out with.

  • Is this sold OTC?

    No, not yet!

  • I'm on Wellbutrin xl and Pretiq 50. Can I take SAMe? I don't know how it interacts with ADs.

    The answer is yes, you can take SAMe! Wellbutrin xl and Pretiq 50 are SSRIs and SNRIs. It is very common to start with these and undermethylation treatment. They work very well together and usually medication can be reduced when nutrient therapy starts working! There are no adverse side effects to nutrient therapy.

  • Hi, how will I know which group I am in? I am MTHFR C677T and have Hashimoto. When I was pregnant I was taking methylfolate kind of folic acid supplement for pregnant women. But no one asked to check some other things to know which group am I exactly. Can you advise me is this product for me and what else I should be taking to feel better? Tnx.

    Autoimmune disorders are typically a undermethylation problem. The c677t mutation also pushes the balance towards undermethylation. We can not tell for sure just based on only these two facts, but check other symptoms in our blog posts. If you are still not sure, there is a SAM/SAH blood test that can confirm your methylation status. A high daily dose of methylfolate is usually helpful only for overmethylated people that are low in folate. Undermethylated people are usually high in folate already, and a high dose of methylfolate will not help at all and can even make you depressed since it suppresses serotonin. Improvement after a while on SAMe will also confirm undermethylation.

  • I have been reading that B12 raises histamine and is helpful for those that are overmethylated. Why does this supplement for undermethylators contain B12?

    For most undermethylated persons, B12 is critical to therapy. However, a moderate dose only. If three tablets seem to be too much over time, perhaps only two tablets are better. The B12 we use is Methyl-B12 which is better for undermethylators than overmethylators. B12 supports methylation, and creates a dramatic improvement in some, but can worsen others if the dose is too high. Overmethylators should use a different form and a higher dose.